World-leading scientists have called for a halt on research to create “mirror life” microbes amid concerns that the synthetic organisms would present an “unprecedented risk” to life on Earth.

The international group of Nobel laureates and other experts warn that mirror bacteria, constructed from mirror images of molecules found in nature, could become established in the environment and slip past the immune defences of natural organisms, putting humans, animals and plants at risk of lethal infections.

Many molecules for life can exist in two distinct forms, each the mirror image of the other. The DNA of all living organisms is made from “right-handed” nucleotides, while proteins, the building blocks of cells, are made from “left-handed” amino acids. Why nature works this way is unclear: life could have chosen left-handed DNA and right-handed proteins instead.

The fresh concerns over the technology are revealed in a 299-page report and a commentary in the journal Science. While enthusiastic about research on mirror molecules, the report sees substantial risks in mirror microbes and calls for a global debate on the work.

    • nickwitha_k (he/him)
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      1710 days ago

      Undergrad in biochemistry with a year research internship. Also, a long, AuADHD-fueled interest with chemistry, industrial microbiology, and reading research papers. Yourself?

      • @[email protected]
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        510 days ago

        Ok, on one side we have undergrad and on other international group of Nobel laureates and other experts. Who is probably right…

        • nickwitha_k (he/him)
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          1310 days ago

          Nobel Laureates have never made ridiculous statements that didn’t mesh well with scientific evidence. Kary Mullis, Nobel Laureate in Chemistry, credited with discovering PCR would never be quoted as refuting the evidence of HIV as causative in AIDS, cited in a journal article questioning the evidence, and then the journal article retracted due to it being inaccurately labeled as “Hypothesis and Theory” instead of opinion, factually inaccurate, and dangerous - oh. Oh no:

          https://pmc.ncbi.nlm.nih.gov/articles/PMC6830318/

          Next thing, you’ll tell me that scientists are humans that are fallible and some of them sometimes engage in ethically-questionable activities and sensationalism for profit.

            • nickwitha_k (he/him)
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              39 days ago

              I’m not sure how I have come off as arrogant. But, I’m fallible just like every other human, including Nobel Laureates. I’m curious to see whether they are actually citing plausible pathogenicity or food web disruption, or if it is just sensationalism from the authors or the science communicator.

          • @[email protected]
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            610 days ago

            i do not disagree, but probability of who is right is not on the side of random lemmy poster in this case.

            • Flying Squid
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              810 days ago

              Let’s refresh your memory on what the original poster you criticized said since you think this is about who is right:

              This seems like something that really is a minimal risk. Pathogens are pathogens because they are able to make use of our bodies as raw materials to reproduce. Unless they are able to make use of both enantiomers in their biology, there’s little benefit to dedicating resources to colonizing us.

              Probably a bigger concern would be outcompeting and displacing organisms lower on the food chain.

              This is someone forming an opinion based on what they know so far. They are clearly a good scientist because they are not making any factual claims here. They are, in fact, doing what any good scientist does and bringing up issues they see with the claims of other scientists.

              They are not even saying it wouldn’t be an overall problem and I would not be at all surprised if they modify their opinion, which was neither a claim nor a prediction, if they read the 299-page report, but you seem to want a formal rebuttal. A formal rebuttal and a peer review process do not require someone to have a degree and people without degrees have had papers published in scientific journals.

              And if they came up with a formal rebuttal and allowed it to be peer-reviewed, would you even read it?

                • Flying Squid
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                  610 days ago

                  Fair enough then! I know I wouldn’t have the knowledge to understand any of it.

            • @[email protected]OP
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              510 days ago

              who is right is not on the side of random lemmy poster in this case.

              Looking at you, kid.

    • @[email protected]
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      10 days ago

      You read what they wrote and became sceptical of their credentials? I mean, it’s healthy to be cautiously sceptical of anything you read/hear to an extent. But to immediately and without any further discussion, call them out in a patronising and condescending way is wild.

      It makes me want to know if you have a background in biology. Since you so readily dispute someone else’s. Someone who, at least on the surface, seems to know what they are talking about.

      In fact, why do you give so much credit to the legitimacy of the article and its writer, there might be a “38 strong group” of nobel laureates and experts warning about this, but the writer of the article adds the spin. The writer decides how to portray the warnings and their urgency. They might be overselling this. And since there is little to no citation in the article, i am more inclined to question the articles’ legitimacy before i query this poster…

        • @[email protected]
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          10 days ago

          I dont think i have given them any credit. I would argue i simply didn’t dispute them out of hand. Especially as you did without backing myself up with evidence of my own credentials.

          I also thought i expressed that we should all be sceptical of anything we read on the internet. My issue was how you weighted your sceptisism. You seem to have automatically given all credibility to a reporter, under the assumption that they held no bias that affected the story they wrote.

          For all you know, the random poster on the internet may be a legitimate scientist and expert who disagrees with them. Their opinion may be just as valid as the opinion in the report.

          As a recent example, google released a quantum computer chip, and lemmy immediately ripped apart the reports and media buzz around what it was actually capable of. I believe that this is a great example of healthy sceptisism.

          I believe that what you did is an example of unhealthy or misplaced sceptisism.

          Granted, if it turned out that this random poster was absolutely unqualified to make the assertions that they did then absolutely you would be in the right.

          I just dont think its helpful to dispute them out of hand with nothing to back you up.

        • nickwitha_k (he/him)
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          510 days ago

          This is actually a fair and good question to ask. Being too credulous of things read on the Internet has shown rather problematic in recent years. Taking everything written in academic journals, especially opinion pieces not based upon peer-reviewed evidence, without skepticism has shown to be problematic since before the Internet, however.

        • @[email protected]
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          29 days ago

          I’m kind of surprised by the reaction you’re getting here as I had the same exact question (you can see that I posted it before seeing yours).

          Knowing that the person has some background in biology helps, but that was not clear in the initial comment. And even still, I lean toward believing the actual professionals who have studied this exact thing for years over some random person on an internet forum.

          • @[email protected]
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            39 days ago

            In fairness, i completely agree that the experts mentioned in the article are more than likely a reliable source of information here and their opinion is almost certainly the one i would side with, not being a biologist by any stretch of the imagination myself.

            However, that’s not really my point. My point is that this person immediately, condescendingly and patronisingly disputed the claim of aomeone who at the very least sounded like they knew what they were talking about, without showing any evidence that they themselves are a reputable source of doubt and without knowing anything about the person they were disputing.

            I dont think that’s a healthy way to discuss things.

            • nickwitha_k (he/him)
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              29 days ago

              In fairness, i completely agree that the experts mentioned in the article are more than likely a reliable source of information here and their opinion is almost certainly the one i would side with

              In all fairness, I also agree with them likely being a solid source of information. There’s been a huge trend of leveraging academic credentials to boost sensationalism in recent years, so, until I read their reasoning, I am skeptical, specifically of whether or not it is blown out of proportion by the authors or the science communicator.

    • Lemminary
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      10 days ago

      Unless they are able to make use of both enantiomers in their biology

      I wouldn’t expect that sentence from someone without a background in biology for many, many reasons.

    • Brumefey
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      510 days ago

      After browsing facebook for one hour I also got to the conclusion that all those people publishing in Science are lying. /s