Summary
Bryan Johnson, a 46-year-old tech multimillionaire focused on anti-aging, stopped using rapamycin—a supplement he took for five years—after research suggested it might accelerate aging.
Johnson cited side effects like skin infections and glucose issues, as well as findings from a recent study showing rapamycin could worsen epigenetic aging.
Known for extreme anti-aging experiments, Johnson also created the health startup Blueprint, which markets pricey supplements.
His controversial methods, including teenage blood transfusions and genital shock treatments, have raised skepticism about their effectiveness and safety.
Is this the trickle down economics everyone is talking about? shall we again start selling uranium, platinum etc beverages to the rich?
He has a team for this?
“Despite the immense potential from pre-clinical trials, my team and I came to the conclusion…"
Forget trickle down economics, this is insane just bring the guillotines.
I see the proud tradition of drinking mercury concoctions is alive and well. I mean, not well, but…
This guy looks like he’s 60 cosplaying as a 20 year old
It would be hilarious if the societal collapse caused by wealth inequality resulted in him getting murdered. I would laugh and laugh.
To think that a societal collapse would stop a billionaire from hiring armed guards is absurd. By the time that guy is murdered, you’ll be so long dead.
Who cares at that point?
This is one of the biggest wastes of time I could imagine.
This dude is just going to spend a bunch of money on shit that will eventually kill him. What a waste.
What an efficient allocation of capital!
That’s what we all do every day, this guy just has more to spend
Nah some of the shit we buy sustains us, and some of the killer shit we buy at least provides joy. This guy is just a miserable, wasteful asshole.
You have to see this guy’s routine. His life is built around attempting to extend his longevity. He lives like a luxurious lab rat being pocked, prodded, measured and eats/drinks/sleeps/exercises on a ultra-strick program.
It seems miserable.
“genital shock treatments”
Ok… how did someone sell that as an anti-aging treatment?
I don’t usually like salespeople, but this one I like a lot.
The salesman: “anti-what?”
The passing of time must be stored in the balls.
Watched the documentary with a friend; we were trying to guess his age. We agreed on “decent looking for 55”. He’s 47 lol.
People who are obsessed with some physical quality about themselves always make whatever the issue is, like 1000% worse than if they just left it alone and lived normally.
His face looks old enough to make his hair look unnatural.
It looks like a wig.
It’s an unpopular opinion, but I actually appreciate this guy and what he is doing. He has opted to open his entire research and data to anyone that wants to look at it. So, even though he is definitely a weirdo, the data he is providing might be of some use.
I don’t want to look like a vampire, but if his research leads to the discovery of some protein that allows my heart to beat at full strength for a little longer, or slows down the onset of dementia, etc., then I’m all for him wasting his money trying to look like a Twilight cast member.
It’s one guy who is going through like a million treatments.
It’s cool that the data is available but what helpful information can be gained from it other than “what happens if you do jackass but healthy?”
I like that he’s willing to really fuck up his own body to see what happens. I don’t like that he’s peddling supplements.
Notice I used the word “appreciate” instead of “like”.
This isn’t real research … it’s just a millionaire spending money on trying to live longer for themselves while selling and marketing products on the side.
If it were real research, it would involve a group of recognized researchers and scientists testing products and activities on a small group of volunteers who are fully aware of what they are participating in. And the research has to last for several years using multiple controls.
Watching one guy testing and trying out a few things whenever he feels like it and done at his own whim and under only his opinion and likes and dislikes is not research.
The biggest contribution he has to longevity is in promoting and advertising the fact that one of the ways to extend your lifespan is to become a millionaire.
Someone testing on themselves is how we learned what causes and how to treat ulcers (the researcher earned a Nobel prize for giving himself an ulcer, and then treating it), among other things.
Controlled trials are great, but research has to start somewhere.
You’re telling me that shocking one’s nards on a hunch and writing it down isn’t real research?
I’m starting to think I know nothing about science. What have I been doing?
I’d love to see your research on shocking your nards … especially to be able to see the video evidence of what happens and what the results are.
If it were real research, it would involve a group of recognized researchers and scientists testing products and activities on a small group of volunteers who are fully aware of what they are participating in. And the research has to last for several years using multiple controls.
For most of the time since the start of the Scientific Revolution, the way this guy does research was the standard way that research was done. Controlled clinical trials certainly have an important role in the development of new medicines, but they’re slow and expensive. They aren’t good tools for quickly trying out a lot of very speculative ideas. I expect that if a powerful anti-aging technique is discovered, it will be used for self-experimentation years before a clinical trial.
A couple of caveats: first, I think that a powerful anti-aging technique is probably not possible with today’s technology or the technology of the near future. Second, I think the self-experimentation is more likely to be done by a scientist in an academic lab studying senescence than by someone doing research outside of academia.
But he’s involving so many variables, is his data even useful? I don’t understand how you could extrapolate anything from a guy who takes so many supplements that may cause conflicting outcomes.
Someone who has a background in science would know that testing on a single person is not very useful for what other posters are wishing for (new proteins, new anti aging treatments).
This billionaire has age dysmorphia and is using his wealth to experiment around. It’s unfortunate really.
It’s unfortunate really.
I don’t know about “unfortunate”. His “move fast and break things” approach to anti-aging treatments have a good chance of killing him, and having one less dipshit billionaire who thinks he’s brilliant because he’s rich would undoubtedly benefit society as a whole.
That’s a good perspective. I hadn’t thought of it that way.
It’s unethical to experiment on anyone other than yourself, but there’s a reason we can cure so many things in mice, and it isn’t just that they’re a bit simpler. It’s also because they go through a lot of mice.
Yes, because anything that looks promising can be pulled out as a hypothesis to be tested properly.
A sample size of one is pretty much useless. The only good thing to come out of his work is the publicity and public interest in anti aging imo.
Single case design is a field of a research that can provide a great deal of value on efficacy for worth of larger trials but the way he’s approaching it, as others have said, is functionally useless. The data is likely pointless if you’ve thrown 100 confounding variables at the wall to see what sticks
I just watched this movie again today, wasn’t expecting a meme of it so quickly!
I know it’s not the popular choice, but Last Crusade is by far my favorite of the Franchise. I re-watch it way more than Raiders.
Had to check this wasn’t nottheonion
It would be hilarious if the accelerated aging from the supplement undid all the progress he made from all the other stuff lol.
I bet I live longer than him, and on a shoestring budget
The guy looks like one of those Kraftwerk robots.
I watched his video describing a day in his life, sleep at 8pm and wake up at 5am, then take 50 pills, his whole day revolved around preparing for sleep, which he said was the most important thing, so I guess he’s right about that. But just thinking a tiny change in his life, even travelling, will upset this routine, then what, the stress from that routine is probably aging him the most.
That’s the thing, he might live a bit longer but at what cost? I would much rather enjoy my life than by a slave to a miserable routine dedicated to promoting longevity that will potentially buy me an extra decade. Like I can just eat a somewhat reasonable diet, exercise, sleep okay and with decent genetics based on my parents and grandparents I will probably make it to at least mid to late 80s, maybe longer if medicine advances. If I had genetics that suggested a strong likelihood that I would die in my 60s I would maybe be more interested
With this guys routine I could maybe push that to 100ish? I would certainly love to extend my life but not at the cost of it consuming my life. I assume he’s banking on getting to the theoretical max though, which is probably closer to 120ish, and that is substantial but then it’s like a few decades of extremely decreased mobility and mental acuity? Eh
And of course this all disregards the potential that you get cancer, murdered, car accident, etc.
I truly believe he loves doing this so no cost to him as far as mental health/stress goes. Sounds like you are doing most things right so that pretty much covers the 80/20 rule. Johnson is trying to live indefinitely without losing mobility or mental faculties. It’s great that we have someone testing things out and adjusting when things don’t work.
